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Vineet Gupta Laboratory 
Vineet Gupta, PhDhttp://www.massgeneral.org/chemicalbiology/ Vineet Gupta is Assistant Professor of Medicine at Harvard Medical School and Assistant in Biology at Massachusetts General Hospital. Dr. Gupta received his M. Sc. in Chemistry from the Indian Institute of Technology in Delhi, India, and his Ph.D. in Chemistry from the University of Rochester in Rochester, NY. His research focuses on chemical approaches to studying inflammatory diseases, with a focus of integrins as targets. The Gupta Lab uses cell-based high-throughput screens to identify small molecules that modulate function of integrins. The lab also uses sophisticated proteomics and bioinformatics tools to elucidate cell signaling networks and pathways. Research The Gupta laboratory works at the interface of chemistry and biology. We develop and apply novel chemical and systems biology tools to obtain a better understanding of the process of inflammation and mechanisms of resolving inflammation. Our research focuses on cellular receptors called integrins and integrin-based cell adhesion. This includes investigations into the mechanism(s) of integrin activation (both structural as well as signaling), discovering novel drug-like small molecules that modulate integrin function, determining the functional consequences of modulating integrin activation in vivo, and proteomic & metabolomic profiling as well as data mining based approaches to model the cellular interactome to identify protein hubs regulating cell adhesion and their role in human disease. A particular focus of the proteomic and metabolomic profiling studies is to identify novel early markers of diabetic nephropathy and of chronic kidney disease in patients. Most of these projects involve collaborations with other laboratories within Boston area as well as outside. These projects are described in more detail on our laboratory’s website (see the URL above). Lab Members Jack Rosa, PhD Research Fellow Amir H. Qureshi Research Assistant Christine Min Undergraduate student intern Max Dyer High school intern |
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