Brian Seed Laboratory


Simches Research Center
Seventh floor
185 Cambridge Street
Boston, MA 02114
phone: 617-643-3300
fax: 617-643-3328

About Brian Seed

Brian Seed is Professor of Genetics at Harvard and the Director and founder of the Center for Computational and Integrative Biology at the Massachusetts General Hospital. A graduate of CalTech, he received both his B.S. and Ph.D. degrees there. Dr. Seed is the author of numerous publications in molecular biology, genomics and proteomics. He holds numerous patents; see his CV for a list. His laboratories include groups in automation, bioinformatics, chemistry, microarrays, proteomics, selection, and sequencing.


Our lab is using new technologies to couple rapid identification of interesting genes with methods for studying the consequences of their expression in an organismic context. We have developed an efficient type of expression cloning of signal transduction intermediates that allows us to rapidly identify cDNAs encoding genes that engage a number of known transduction pathways.

In addition, we continue to work on methods for creating mutant cell lines that have lesions in signal transduction pathways, and on appropriate ways to uncover the genetic basis of those lesions.

We are also developing systems for rapid generation of mice bearing targeted disruptions of specific candidate genes. Many of the latter projects are directed at large-scale changes in the mouse genome, which will help us create better mouse models of human disease.

In conjunction with the CCIB chemistry and therapeutics group we have been working on new strategies to treat disease using novel biologicals and pharmaceuticals.

Lab Members

Linda Chun, PhD Assistant in Molecular Biology
Isin Dalkilic-Liddle, PhD Research Fellow
Sandip Datta, PhD Research Fellow
Yao-Ting Huang, PhD Research Fellow
Hwijin Kim, PhD Research Fellow
Naifang Lu Research Lab Manager
Soon-Young Na, PhD Research Fellow
Rasma Niedra Research Lab Technologist
Changhong Pang, PhD Research Team Leader I
Slim Sassi, PhD Research Fellow
Prabhat Kumar Singhal, PhD Research Fellow
Athanasia (Nancy) Spandidos, PhD Research Fellow
Ming-Hsiang (Vicky) Sung, PhD Research Fellow
Huajun Wang, PhD Bioinformatics Specialist
Guo Ling Zhou, PhD Research Fellow

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