Simches Research Center
185 Cambridge Street, 8th Floor
Boston, MA 02114
phone: 617-726-5788
fax: 617-726-5708

About Ralph Weissleder

Dr. Weissleder is a Professor at Harvard Medical School and Director of the Center for Systems Biology, the newest MGH thematic research center. He is also the Director of the MGH Center for Molecular Imaging Research, and is clinically active as an Attending Interventional Radiologist in the MGH Department of Radiology. He is an active member of many Boston-area research communities, including the Dept. of Systems Biology at Harvard Medical School, the Broad Institute of Harvard and MIT, the Dana-Farber-Harvard Cancer Center, and the Harvard Stem Cell Institute (HSCI).

He has published over 500 publications in peer-reviewed journals, has authored and co-authored several textbooks, and holds 15 patents. He is a founding member of the Society for Molecular Imaging Research and served as its President in 2002. His work has been honored with numerous awards including the J. Taylor International Prize in Medicine, the Millennium Pharmaceuticals Innovator Award, the AUR Memorial Award, the ARRS President's Award, the Society for Molecular Imaging Lifetime Achievement Award, and the Academy of Molecular Imaging 2006 Distinguished Basic Scientist Award.


Dr. Weissleder's research has focused on applying novel molecular imaging and nanotechnology tools to the study of complex human diseases. He has made fundamental discoveries in early disease detection, and the development of nanomaterials for sensing and systems analysis. His research has been translational and several projects have led to advanced clinical trials.

The Weissleder Laboratory currently has three major areas of interest:
  1. An NIH-funded program to develop nanomaterials and other scaffold-based libraries to identify novel ligands for interrogation of cellular pathways and to use this information to develop a more comprehensive understanding of in vivo cancer biology
  2. An effort to analyze the genes and gene products involved in the molecular pathogenesis of complex human diseases in order to identify novel imaging and therapeutic targets
  3. A program to develop novel miniaturized sensing technologies such as chips for real-time high-throughput analysis of problems in biology
The lab develops and uses a variety of tools and platforms for data acquisition. In particular, we aim to obtain the following information using in vivo systems through bioimaging and parallel sensing:
  • Quantitative measurements
  • Systems-wide global measurements
  • Integration of multiple different data sets into models
  • Dynamic, serial measurements
  • Systems perturbations
  • Integration of discovery and hypothesis-driven research

Lab Members

Deliolanis, Nikolaos, PhD Research Fellow
Devaraj, Neal, PhD Research Fellow
Figueiredo, Jose-Luiz, MD Staff Scientist
Keliher, Edmund, PhD Research Fellow
Lee, Hakho, PhD Research Fellow
Vinegoni, Claudio, PhD Research Fellow
Yoon, Tae-Jong, PhD Research Fellow

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